Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology
نویسندگان
چکیده
منابع مشابه
Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology.
BACKGROUND AND PURPOSE The entorhinal cortex, a critical gateway between the neocortex and hippocampus, is one of the earliest regions affected by Alzheimer disease-associated neurofibrillary tangle pathology. Although our prior work has automatically delineated an MR imaging-based measure of the entorhinal cortex, whether antemortem entorhinal cortex thickness is associated with postmortem tan...
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Neurodegenerative disorders are characterized clinically by insidious onset and slowly progressive course, and are frequently hereditary. Pathologically, these diseases share a common feature: the selective loss of a particular subset of neurons for unknown reasons [e.g. cerebral cortical neurons in ALZHEIMER’S DISEASE (AD) (see Glossary), substantia nigra neurons in PARKINSON’S DISEASE (PD), s...
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INTRODUCTION In early stages of Alzheimer's disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later stages, when clinical symptoms generally occur, NFT involve widespread limbic and association cortices. At this point in the disease, amyloid plaques are also abundantly distributed in the cortex. This observation from human n...
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ژورنال
عنوان ژورنال: American Journal of Neuroradiology
سال: 2017
ISSN: 0195-6108,1936-959X
DOI: 10.3174/ajnr.a5133